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    抗PAD3抗体可预测RA患者的关节破坏
    发布时间:[2016-04-01 17:16] 点击次数:

     

    摘要目的:

    肽酰基精氨酸脱亚胺酶(PAD)是钙依赖性的催化蛋白瓜氨酸化的一种酶。近期有关于抗PAD3/4抗体的报道,针对PAD3和PAD4的抗体存在交叉反应从而增加与关节破坏相关的PAD4的活性。本研究的目的是分析抗PAD3抗体水平与关节破坏的相关性。

     


     

     

    方法:

    为了验证新型化学发光免疫测定法(CIA)检测抗PAD3抗体的可靠性,我们先将20个样本同时用CIA法和免疫沉淀(IP)法进行检测。再纳入39例类风湿关节炎(RA)患者,记录关节侵蚀评分(JES)、总Sharp评分(TSS)及关节间隙狭窄评分(JSNS)并检测抗CCP抗体及抗PAD3抗体水平。

     

     

     

     

    结果:

    用CIA和IP法检测抗PAD3抗体的结果一致性非常好(rho=0.85, p<0.0001)。纳入的39例RA患者的JES中位数为14,1,标准差为11.5。抗PAD3抗体水平与JES相关,但与TSS及JSNS无相关性。在本研究中,用不同方法检测的抗CCP抗体水平与JES无明显相关。

     

     

     

     

    结论:

    抗PAD3抗体与关节侵蚀评分显著相关,因此,抗PAD3抗体有可能成为预测RA患者关节破坏的指标。

     

     

     

     

    附原文:

    Abstract BACKGROUND: Recently, antibodies directed against peptidyl arginine deiminase 3 and 4 (anti-PAD3/PAD4 antibodies), calcium-dependent enzymes that catalyze the conversion from peptidyl-arginine to peptidyl-citrulline, have been described. Furthermore, antibodies that cross-react between PAD3 and PAD4 cause increased PAD4 activity correlate with joint damage. This study analyzes the correlation of anti-PAD3 antibodies with joint damage. METHODS: To validate the novel chemiluminescent immunoassay (CIA) for the detection of anti-PAD3 antibodies, 20 samples were tested by CIA and by immunoprecipitation (IP). Next, 39 RA patients with available joint erosion score (JES), Total Sharp Score (TSS) and Joint Space Narrowing Score (JSNS) were tested for anti-CCP (using different methods) and anti-PAD3 antibodies by CIA. RESULTS: Excellent correlation was observed between the CIA and IP for the detection of anti-PAD3 antibodies (rho=0.85, p<0.0001). The median JES of our 39 patients was 14.1 with a standard deviation of 11.5. Anti-PAD3 antibody levels (rho=0.39, 95% CI 0.1-0.6; p=0.0149) were correlated with JES. No correlation was found with TSS and JSNS. In this cohort, ACPA measured using different anti-CCP assays did not correlated with the JES. CONCLUSION: In our cohort, anti-PAD3 antibodies correlate with joint erosion score. Therefore, anti-PAD3 antibodies might represent promising markers to predict joint damage in RA patients.

     

     

     

     

    引自:

    Seaman  ADarrah EInfantino M, et al. Anti-peptidyl-arginine deaminase 3 (PAD3) antibodies as a promising marker to measure joint damage in patients with rheumatoid arthritis. Autoimmun Rev. 2016 Mar 17.

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